Late Show with David Letterman Season 22, Episode 106: Neil Patrick Harris, Charlie Cox, the Suffers

Luke Wilson, Julie Chen, Lee Brice

Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers

Steve Buscemi, Indy Car Season Champ, Alt-J

Tina Fey, Moody McCarthy, Kevin Drew

Bill Maher, Henrik Lundqvist, Spoon

Michael Strahan, Richard Branson, Interpol

Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson

Jason Bateman, Billy Eichner, Ryan Adams

Mindy Kaling, Jake Johannsen, Maddie & Tae

Mark Harmon, "Jungle" Jack Hanna

Denzel Washington, Lenny Kravitz

Kelly Ripa, Jim Gaffigan, Paloma Faith

Jerry Seinfeld, Michael Jackson ONE

Ted Danson, Andrew Norelli

Neil Patrick Harris, Jamie Oliver, Aretha Franklin

John Oliver, Maggie Q, Bleachers

Bill O'Reilly, Cristin Milioti

Johnny Galecki, Andre Benjamin, Delta Spirit

Mariska Hargitay, Simon Amstell, Kandace Springs

Aziz Ansari, Tom Dreesen

Robert Downey Jr., Sarah Paulson, Lizzo

Anderson Cooper, Gina Rodriguez, Hatsune Miku

Robert Duvall, Elle Fanning, Rival Sons

Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley

TV host Chelsea Handler; comics Keegan-Michael Key and Jordan Peele; Angaleena Presley performs.

Russell Brand, Dave Grohl, Foo Fighters

Michael Keaton, Foo Fighters

Bill Murray, Foo Fighters

Tom Selleck, Jenny Slate, Foo Fighters

Jessica Chastain, Lenny Marcus, Foo Fighters

Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis

Taylor Swift, Tom Mison

Jim Carrey, David Tennant

Brian Williams, Perfume Genius

Keith Olbermann, Brian Regan, Run the Jewels

Martin Short, Father John Misty

Jennifer Lopez, Rob Riggle, Kimbra

Whoopi Goldberg, Jimmy Page, Mapei

Amy Schumer, Jeff Caldwell

Katie Holmes, Alex Zanardi

Steve Carell, Martha Stewart, OK Go

Jennifer Lawrence, Boris Johnson

Jon Stewart, Shawn Mendes

Kristin Chenoweth; Chris Young

Actress Kristin Chenoweth; Chris Young performs.

Jason Sudeikis, Allison Janney, Damien Rice

Stupid Pet Tricks, Charlie Day, Hiss Golden Messenger

Regis Philbin, Hundred Waters

Edward Norton, Jessye Norman

Norman Lear, TV on the Radio

Seth Rogen, Amy Sedaris

Emily Blunt, Adam Resnick, Wu-Tang Clan

Jake Gyllenhaal, Dr. John P. Holdren, Nico & Vinz

Joaquin Phoenix, Cristela Alonzo, Al Green

Ben Stiller, Olivia Munn, LaLa Brooks

Meryl Streep, Rebel Wilson, J. Cole

Chris Rock, Sting

Jamie Foxx, Robert Klein, Dan Penn

Emma Stone Top, Marcus Mariota, Bob Seger

New Holiday Toys, Anna Kendrick, Charli XCX

Tom Brokaw, Will Nelson & Billy Joe Shaver

Rosie O’Donnel,l Jeff Altman

Jay Thomas, Josh Brolin, Darlene Love

The final Christmas episode. Jay Thomas drops by to once again tell "The best talk show story, ever", then he and David try to knock the meatball off the Christmas tree in the Late Show Quarterback Challenge. An interview with Josh Brolin. The show wraps up with Darlene Love's last Late Show performance of Christmas (Baby Please Come Home).

Kathy Griffin, David Oyelowo, Lera Lynn

Ethan Hawke, Allison Williams, Parquet Courts

Julianne Moore, Catfish & the Bottlemen

Donald Trump, Chelsea Peretti, Foxygen

Michael Somerville, Nicole Atkins

Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones

Anderson Cooper, Shovels & Rope

Amanda Peet, Ryn Weaver

Larry David, Dan Patrick, Sleater-Kinney

Urban Meyer, Johnny Beehner, Ella Henderson

Louis CK, Nicolle Wallace, the Lone Bellow

Andrew Luck, Oscar Isaac, Drenge

Viola Davis, Ben Schwartz, Marty Stuart

John Oliver, Mayim Bialik, Death Cab for Cutie

Aziz Ansari, Brian Kiley, Ben Howard

Jack Hanna, Sharon Jones and the Dap-Kings

Dr. Phil McGraw, Robin Tunney, Diana Krall

Ryan Reynolds, Dierks Bentley

Martin Short, Bettye Lavette

Sienna Miller, Andy Kindler, Bob Mould

Steve Carell, Dr. Cornel West

Courtney Love, Chris Elliott, Rhiannon Giddens

Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear

Tom Hanks, Sturgill Simpson

Bill Hader, Pat McGann, Shakey Graves

Matthew Perry, Adam Scott, Kishi Bashi

Dakota Johnson, David Tochinskiy, Twin Shadow

Will Smith, Grizfolk

Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko

Kid Scientists, Sean Hayes, Judah & the Lion

Helen Mirren, the 2015 Daytona 500 winner, Steve Earle

Matthew Broderick, Ellie Kemper, JD McPherson

Julianna Margulies, Eric Ripert, Glass Animals

Kevin Spacey, Lily James, Alabama Shakes

Patricia Arquette, Will Butler

Kelsey Grammer, Stevie Wonder

Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew

Kevin Bacon, Jimmie Walker, Airborne Toxic Event

Shailene Woodley, Dr. Cornel West, Matthew E. White

Will Ferrell, Glen Hansard

Norm MacDonald, Theo James

Ben Stiller, Tove Lo

Bill O'Reilly, Aubrey Plaza

James Franco, Jake Johannsen, Action Bronson

David Duchovny, Josh Gad, Houndmouth

Sen. Al Franken, Billy Eichner, David Sanborn

Kelly Ripa, Aasif Mandvi, Fat White Family

Mike Myers, Nick Griffin, Banks

Sarah Jessica Parker, Julie Chen, Asleep at the Wheel

Billy Crystal, Chris Russo, Chris Stapleton

Michael J. Fox, Iron & Wine, Ben Bridwell

Kevin James, Tom Dreesen, Tracy Chapman

Alec Baldwin, John Mayer

John Travolta, Amy Schumer, the Waterboys

Piedmont Bird Callers, Paul Rudd

Bruce Willis, Dawes

Robert Downey Jr., Chris Russo, Elvis Costello

Jerry Seinfeld, Jason Isbell & Amanda Shires

Scarlett Johansson, John Mellencamp, Todd Rundgren

Michael Keaton, Future Islands

Jack Hanna, John Popper

First Lady Michelle Obama Hootie and the Blowfish

Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor

President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile

Reese Witherspoon, Nathan Lane, Mumford & Sons

Martin Short, Norah Jones

Tina Fey, First Aid Kit

Ray Romano, Brian Regan, Dave Matthews Band

Howard Stern, Don Rickles

Bill Clinton, Adam Sandler

Julia Roberts, Paul Shaffer, Ryan Adams

Al Pacino, George Clooney, Tom Waits

Oprah Winfrey, Norm Macdonald

Tom Hanks, Eddie Vedder

Bill Murray, Bob Dylan

The Final Late Show with David Letterman

6,028th broadcast

Episode 149

The final episode includes surprises, memorable highlights and the last Top Ten List.