The Tonight Show with Jay Leno Season 15, Episode 29: Penelope Cruz, John Stamos, "Weird Al" Yankovic

Jason Lee, Elton John

Justin Timberlake, Sarah Silverman

Steve Carell, Jamie Lee Curtis, Joan Jett

Teri Hatcher, Jon Heder, Kenny Chesney

Calista Flockhart, Harland Williams, Gomez

Eva Longoria, Cole and Dylan Sprouse, Death Cab for Cutie

Adrien Brody, Chef G. Garvin, Alan Jackson

Evangeline Lilly, Magic Johnson, Diana Krall

Ashton Kutcher, Jenna Fischer, Amos Lee

Jessica Simpson, Bill O'Reilly, Snow Patrol

Wanda Sykes, Chris Matthews, John Mayer

Helen Mirren, B.J. Novak, Jet

Michael Clarke Duncan, Lisa Lampanelli, Rod Stewart

Bob Newhart, Kristin Chenoweth, Camp Freddy

Jarod Miller, Bradley Whitford, Ray LaMontagne

Tina Fey, Annika Sorenstam, Fergie

Tiger Woods, Emeril Lagasse, Chingy

Arnold Schwarzenegger, Heidi Klum, Le Rêve

Sandra Bullock, Michael Caine, Chris Young

David Gregory, Ali Larter, Edie Brickell & The New Bohemians

Hugh Jackman, Tim McGraw

Jennifer Love Hewitt, Tim Burton, Barry Manilow

Annette Bening, Mad Scientist David Willey, Sarah McLachlan

Sally Field, Bug Man Ruud Kleinpaste, Kevin Federline

John Landis & The Spiridellis Brothers, JoJo

Tim Allen, 8-year-old opera singer Gwyn Mackenzie, Carrie Underwood

Roseanne Barr, Sharon Osbourne, Marilyn Manson

Emma Thompson, Spencer Breslin, Regina Spektor

Russell Crowe, Rachael Ray, Kellie Pickler

Hugh Laurie, America Ferrara, the Cheetah Girls

Hugh Laurie; America Ferrara; the Cheetah Girls.

Courtney Love, Brad Garrett, OK Go

Ellen DeGeneres, Fred Willard, Tony Bennett

Borat, Martha Stewart, Damian Rice

Lindsay Lohan, Emmitt Smith, Army Of Anyone

Sharon Stone, Patricia Arquette, Vince Gill

Rachel Weisz, Nick Cannon, Il Divo

Jaime Pressly, Adventurer Bear Grylls, Cirque du Soleil: The Beatles - LOVE

Emilio Estevez, D.L. Hughley, Josh Groban

Kate Winslet, Wilmer Valderrama, Buddy Guy

Demi Moore, Ron Livingston, Chris Cornell

Denzel Washington, Catherine O'Hara, Jerry Lee Lewis with Kid Rock

Amazing Animals With Julie Scardina, Ellen Pompeo, Nelly Furtado

Howie Mandel, Nelly Furtado

Kristin Davis, Ralphie May

Cameron Diaz, Gwyn Mackenzie, The Wreckers

Lucy Liu, Bob Saget, Snoop Dogg

Al Gore, Karolina Kurkova, Fantasia

Morgan Freeman, Josh Duhamel, Barenaked Ladies

Sen. Barack Obama, Maggie Gyllenhaal, Taylor Hicks

Cate Blanchett, Larry the Cable Guy, Corinne Bailey Rae

Dennis Miller, LaDainian Tomlinson, K.T. Tunstall

Jack Black, Chef G. Garvin, Paulina Rubio

Mel Gibson, Bil Dwyer, Ludacris

Sylvester Stallone, Parminder Nagra, Seal

Former President Jimmy Carter, Edward Norton, Panic! At the Disco

Jamie Foxx, Brad Paisley

Dakota Fanning, Aaron Eckhart, Twisted Sister

Leonardo DiCaprio, Naomi Watts, The Goo Goo Dolls

Tobey Maguire, spider expert Jules Sylvester, Sarah McLachlan

Samuel L. Jackson, Nick Thune, Scott Weiland

Robert De Niro, Jennifer Hudson

Will Smith, Pamela Anderson, Richard Roeper, The Blind Boys of Alabama

Matthew McConaughey, Opie and Anthony, The Killers

Dustin Hoffman, Abigail Breslin, African Children's Choir

George Clooney, Maria Lark, Unwritten Law

Justin Timberlake, Masi Oka, Matisyahu

Hilary Swank, Tom Papa, Akon

Terry Bradshaw, baker Marjorie Johnson, Papa Roach

Kiefer Sutherland, Betty White, Chris Daughtry

Ben Affleck, Chris Leak, Jewel

Sen. John Edwards, Terri Irwin, Mindy Smith

Helen Mirren, Isaac Mizrahi, Los Lonely Boys

Renée Zellweger, Joy Behar, Common

Paula Abdul, D.L. Hughley, Tyrese feat. Lil Jon

Matt Lauer, John & Margaret Ragonese, The All-American Rejects

Meredith Vieira, Ryan Reynolds, Robin Thicke

James Woods, Lisa Lampanelli, Five For Fighting

Don Rickles, John Stamos, Rocco DeLuca & The Burden

Jennifer Garner, Ty Pennington, Bow Wow

Jon Cryer, Jeff Garcia, Switchfoot

Sienna Miller, Phyllis Diller, Branford Marsalis Quartet

Actress Sienna Miller ("Factory Girl"); Phyllis Diller; Branford Marsalis performs "Fate" from his CD Braggtown; Jay Interviews George W. Bush.

Wanda Sykes, Sendhil Ramamurthy, The Bird And The Bee

Rebecca Romijn, Bob Saget, Rodrigo Y Gabriela

Bill Cosby, Mary Lynn Rajskub, Katharine McPhee

Diane Keaton, Ivanka Trump, The Soweto Gospel Choir

Forest Whitaker, America Ferrera, Daniel Powter

Abigail Breslin, Amazing Animals With Julie Scardina, Christina Aguilera

Cuba Gooding Jr., Miss USA Tara Conner, The Game

Clint Eastwood, Jennifer Hudson, John Waite and Alison Krauss

Penelope Cruz, Tyler Perry, James Hunter

Hugh Grant, Himalayan Bears With Julie Scardina, Norah Jones

Mark Wahlberg, Sarah Silverman, Mat Kearney

Drew Barrymore, Kyle Krichbaum, Solomon Burke

Nicolas Cage, D.J. Sampson & Sam Ballerini, The Fray

Dennis Miller, baker Marjorie Johnson, Taylor Swift

Beyoncé, Charles Barkley, Kenny Wayne Shepherd

Jim Carrey, Gov. Tom Vilsack, Dustin Kensrue

Teri Hatcher, Rhys Ifans, Omarion

Simon Cowell, Randy Jackson & Ryan Seacrest, Tiki Barber, Silversun Pickups

Bill Maher, skydiving accident survivor Michael Holmes, Rodney Atkins

Jaime Pressly, Gordon Ramsay, Gomez

Peter O'Toole, Christina Ricci, Hellogoodbye

Animals With Joan Embery, William H. Macy, John Mellencamp

Courteney Cox, Richard Roeper, Plain White Ts

John Travolta, Katt Williams, Everclear

Tim Allen, Hollywood's Most Talented Animals, Fergie

Howie Mandel, Chris Hansen, Korn

Queen Latifah, Gerard Butler, Buckcherry

Mark Wahlberg, Brad Garrett, My Chemical Romance

Sandra Bullock, Andy Richter, Evanescence

Minnie Driver, Bailee Madison, Finger Eleven

Dan Rather, bizarre food expert Andrew Zimmern, Lloyd

Terry Bradshaw, Mary Lynn Rajskub, Musiq Soulchild

Terrence Howard, Bruce Fine, the cast of "Jersey Boys"

David Spade, Richard Engel, Hinder

Roseanne Barr, Heather Mills, James Morrison

Will Ferrell, Sen. Joseph Biden, Paolo Nutini

Nick Nolte, bug expert Rudd Kleinpaste, Guster

Quentin Tarantino, Pete Rose, Mika

Jeff Foxworthy, Charlie Engle, Kevin Lin & Ray Zahab, Dierks Bentley

Hilary Swank, Carlos Mencia, Gym Class Heroes

Campbell Brown, Will Arnett, Dave Koz feat. Johnny Mathis

Amy Poehler, Ricky Schroder, Ozomatli

Kurt Russell, Shia LaBeouf, Hilary Duff

Gerard Butler, Tim McGraw

Jennifer Love Hewitt, Brandi Carlile

Craig T. Nelson, Molly Shannon, Sick Puppies

Jeremy Piven, Jenna Fischer, John Legend

Jeremy Piven; Jenna Fischer; John Legend.

Anthony Hopkins, Rose McGowan, Good Charlotte

Anthony Hopkins; Rose McGowan (Grindhouse); Good Charlotte performs a song from their new album, Good Morning Revival; Headlines.

Jamie Lee Curtis, Jonathan Rhys-Meyers, Patty Griffin

Wanda Sykes, Jesse James, Rickie Lee Jones

Julia Louis-Dreyfus, Rep. Nancy Pelosi, Relient K

Rainn Wilson, Orny Adams, The Shins

Luke Wilson, Alexandra Wentworth, Lily Allen

Tim Russert, Eddie Izzard, Three Days Grace

Tobey Maguire, Tori Spelling, Wicked

Jack Black, Sanjaya, OK Go

Kevin Bacon, Hayden Panettiere, Michael Phelps

Zach Braff, Pat Summitt, Joss Stone

Bill Maher, Sig & Edgar Hansen, Amy Winehouse

Leah Remini, Adam Brody, Mavis Staples

Leah Remini (The King of Queens); Adam Brody (In the Land of Women); Mavis Staples performs a song from her cd We'll Never Turn Back

Jarod Miller, Kiefer Sutherland, Macy Gray feat. Natalie Cole

Conan O'Brien, Venus Ramey, Kings of Leon

Eric Bana, Oscar De La Hoya, Kaiser Chiefs

Dr. Phil McGraw, Rove McManus, Patti Smith

Mitt Romney, D.L. Hughley, Fall Out Boy

Howie Mandel, Bryce Howard, Alan Jackson

Thomas Haden Church, 102-year-old golfer Elsie McLean, Ne-Yo

Mike Myers, Floyd Mayweather, The Cat Empire

Matthew Fox, Larry the Cable Guy, Feist

Antonio Banderas, Brady Barr, Aqualung

Cameron Diaz, 6-year-old piano prodigy Ethan Bortnick, Nelly Furtado

Amazing Animals With Julie Scardina, Gov. Bill Richardson, Miranda Lambert

Dominic Monaghan, "American Idol" finalists Melinda Doolittle, Blake Lewis & Jordin Sparks, Taylor Hicks

Orlando Bloom, Maria Lark, Gym Class Heroes

Ricki Lake, baker Marjorie Johnson, Gretchen Wilson

Felicity Huffman, bizarre food expert Andrew Zimmern, Dolores O'Riordan

Jamie Foxx, Jimmy Fallon, Peter Bjorn And John

Simon Cowell, 95-year-old college graduate Nola Ochs, Maroon 5

Demi Moore, Judd Apatow, Angelique Kidjo feat. Ziggy Marley

Gov. Arnold Schwarzenegger, Debra Messing, Fiction Plane

Kevin Costner, "American Idol" winner Jordin Sparks, Daniel Tosh

Dennis Miller, Ross "The Intern" Mathews, Dwight Yoakam

Jessica Alba, Seth Rogen, Lucinda Williams

Jessica Alba (Fantastic Four); Seth Rogen (Knocked Up); Lucinda Williams performs from her new album West; Headlines.

George Clooney, senior-citizen band the Zimmers, Rihanna

Bernie Mac, Cat Deeley, Chris Cornell

Don Rickles, Josh Flitter, Dashboard Confessional

Steve Carell, Kenny Smith, The Goo Goo Dolls

Wanda Sykes, Mathias Sisters, John Mayer

Fred Thompson, Lauren Graham, Toby Keith

Terry Bradshaw, Shia LaBeouf, James Morrison

Téa Leoni, Joy Behar, Bloc Party

Bill Cosby, Charlie Gilpin, Aspen Nelson & Bryant Ashton, Avril Lavigne

Robin Williams, Chelsea Handler, Big & Rich

Michael Chiklis, Bruce Bowen, Sugarland

Michael Chiklis (Fantastic Four); San Antonio Spurs Bruce Bowen; Sugarland perform from the album Enjoy the Ride; Jaywalking: Viva Las Vegas.

Samuel L. Jackson, 17-year-old reptile expert Corbin Maxey, Jesse Malin

John Cusack, Tavis Smiley, Lifehouse

Cedric the Entertainer, Chip Foose, Kelly Clarkson

John & Elizabeth Edwards, Maz Jobrani, The Red Jumpsuit Apparatus

Michael Moore, Justin Long, Mandy Moore

Josh Duhamel, David Willey, Jason Aldean

Dr. Phil McGraw, Leslie Mann, Velvet Revolver

Ethan Hawke, Carlos Mencia, Breaking Benjamin

Daniel Radcliffe, Patton Oswalt, The Decemberists

Adam Sandler, Nikki Blonsky, Silverchair

John Travolta, Tony Dungy, The Neville Brothers

Jessica Biel, Bill Engvall, T-Pain feat. Yung Joc

Bill Maher, Minnie Driver

Holly Hunter, Kent Couch, Ryan Adams & The Cardinals

Sandra Bullock, Chris Matthews, Suzanne Vega

Don Cheadle, Miley Cyrus, Puddle of Mudd

Glenn Close, Sebastian Manisalco, Marilyn Manson

Amazing Animals With Julie Scardina, Aaron Eckhart, Common

Rob Schneider as Lindsay Lohan, Rove McManus, Sum 41

Matt Damon, George Foreman, Stephen Stills

Michael Moore, Orny Adams, Perry Farrell's Satellite Party

Kevin James, Arctic swimmer Lewis Pugh, Katharine McPhee

Jennifer Lopez, Kevin Nealon, Glen Hansard & Markéta Irglová

Chris Tucker, Marc Anthony, The John Butler Trio

Heidi Klum, Anderson Cooper, Brad Paisley

Claire Danes, Bob Saget, Grace Potter & The Nocturnals

Hank Azaria, David Hasselhoff, Sharon Osbourne & Piers Morgan, Daddy Yankee

Michelle Pfeiffer, Jonah Hill, MIMS

Cuba Gooding Jr., Zac Efron, John McLaughlin

Seth Rogen, animal trainer Jules Sylvester, Hot Hot Heat

David Duchovny, Tiki Barber, Nick Thune

Rainn Wilson, Gordon Ramsay, Fuel

Drew Carey, Richard Roeper, Colbie Caillat

Sen. John McCain, Bill Hader, Ben Harper and the Innocent Criminals

Jeff Foxworthy, Maria Lark, Mat Kearney

Jonah Hill, Michael Cera, Christopher Mintz-Plasse, Jarod Miller, Wilco

Seth Green, Mike Rowe, Collective Soul

Dennis Miller, Capt. Ed Kiesel, Rodrigo Y Gabriela

Fred Thompson, Jerome Bettis, Travis Tritt

Daniel Radcliffe, Mark Cuban, Kings of Leon

Show# 3431

Dr. Phil McGraw, Chandra Wilson, Joe Henry

Brad Garrett, Funny Car racer Ashley Force, Cirque du Soleil

Denis Leary, Robert Klein, Spoon

Kelsey Grammer, Dan Fogler, The Bravery

Terry Bradshaw, Vanessa Hudgens, Michael Buble

Michael Douglas, Tavis Smiley, Good Charlotte