The Tonight Show with Jay Leno Season 16, Episode 20: Christina Applegate, Bill O'Reilly, Alicia Keys

Howie Mandel, Amanda Bynes, Emmylou Harris

Jamie Foxx, Tim Gunn, Paolo Nutini

Dane Cook, Ali Larter, LCD Soundsystem

Jessica Alba, D.L. Hughley, Cold War Kids

Hugh Laurie, Sherri Shepherd, The Editors

Dwayne "The Rock" Johnson, Dennis Kucinich, Diana Krall

Jennifer Love Hewitt, Jeff Corwin, Reba McEntire with Vince Gill

Steve Carell, Madison Pettis, Bright Eyes

Ben Stiller, Tony Snow, Raul Midon

Teri Hatcher, Kevin McKidd, Queen Latifah

Patricia Heaton, Emeril Lagasse, Tori Amos

Tom Selleck, Carlos Mencia, Bobbie and Willie Nelson

John Larroquette, Chelsea Handler, Matchbox Twenty

Cate Blanchett, Tyler Perry, Annie Lennox

Ben Affleck, Jim Norton, The Shins

Jaime Pressly, Brady Barr, Blue Man Group

Dana Carvey, Malin Akerman, Plain White T's

Joaquin Phoenix, Gordon Ramsay, Vanessa Carlton

James Spader, Lara Logan, Steve Byrne

Reese Witherspoon, David Koechner, PJ Harvey

Sen. Barack Obama, Orny Adams, Keith Urban

Jerry Seinfeld, Amy Ryan, Evanescence

Halle Berry, Greg Grunberg, Dwight Yoakam

Russell Crowe, Jenna Bush, Carrie Underwood

Tom Cruise, Rep. Ron Paul, Sex Pistols

Eva Mendes, Marjorie Johnson, Barry Manilow

Denzel Washington, Dave Salmoni, LeAnn Rimes

Steve Carell, Manny Ramirez, Backstreet Boys

Gov. Mike Huckabee, Emeril Lagasse, Chingy

Howie Mandel, Jason Lewis, Joe Nichols

Animals With Jarod Miller, John Caparulo, Blake Lewis

Ron Paul, Christopher Titus, Shakira

Pamela Anderson, Mary J. Blige

Jules Sylvester and animals, Maria Bartiromo, Finger Eleven

Jimmy Kimmel, Elon Gold, OneRepublic

Arsenio Hall, Melanie Metz & Peggy Willenberg, Seether

Marilu Henner, Brady Barr, Jordan Sparks

Bill Maher, Carrie Ann Inaba & Bruno Tonioli, Taylor Swift

Chris Matthews, John Roy, Jill Scott

D.L. Hughley, Joe Ligotti, Sara Bareilles

Mitt Romney, Ryan Sheckler, Jonas Brothers

Simon Cowell & Ryan Seacrest, Tavis Smiley, Shaggy

David Gregory, Performing Birds, Puddle Of Mudd

Adam Carolla, Richard Roeper, Shooter Jennings

Animals With Julie Scardina, Chelsea Handler, Buckcherry

Hulk Hogan, Mad Scientist David Willey, Natasha Bedingfield

Chazz Palminteri, Alison Sweeney, Dierks Bentley

Lester Holt, Blue Ribbon Baker Marjorie Johnson, Raheem DeVaughn

Animals with Dave Salmoni, Tom Green, Maroon 5

Sen. John McCain, Rudy Giuliani, Shelby Lynne

Tom Brokaw, Terrell Owens, Graham Colton

Dan Rather, Mike Rowe, Josh Kelley

Insects with Brent Karner, Stephen Baldwin, J. Holiday

Frank Caliendo, Chimp Rescuer Eugene Cussons, Flo Rida

Arsenio Hall, Paula Deen, James Blunt

Brian Williams, Ahmed Ahmed, Enrique Iglesias

Larry the Cable Guy, Bobby Knight, Andrea Bocelli

Larry the Cable Guy, Bruno Tonioli, Glen Hansard & Markéta Irglová

Joan Embery and Animals, Larry the Cable Guy, Mika

Russell Crowe, Larry the Cable Guy, Willie Nelson

Kristen Chenoweth, Russell Peters, Lifehouse

Reese Witherspoon, Alex Cambert, Gary Allan

Will Ferrell, Hayden Christensen, The Hives

Garth Brooks, Christina Ricci

Heidi Klum, James McAvoy, John Fogerty

Colin Farrell, Bill O'Reilly, Herbie Hancock

Eric Bana, Catherine O'Hara, Tift Merritt

Dennis Quaid, David Koechner, Lupe Fiasco

Billy Ray Cyrus, Miley Cyrus, Brooke Shields

Wanda Sykes, Bryan Cranston, Cat Power

Dave Salmoni and Animals, Patricia Arquette, The Punch Brothers

Dominic Monaghan, Ethan Bortnick, Sheryl Crow

America Ferrera, Bob Saget, The Blind Boys of Alabama

Bill Cosby, Novak Djokovic, Landon Pigg

Howie Mandel, Minnie Driver

Gordon Ramsay

Kate Beckinsale, Carlos Mencia, The Bravery

Terry Bradshaw, James Carville & Mary Matalin, Michael McDonald

Ryan Phillippe, Lisa Lampanelli, Jim Lauderdale

John Edwards, Leslie Mann, Nada Surf

Adam Carolla, Geraldo Rivera, The Black Crowes

Peter O'Toole, Katt Williams, Leona Lewis

Abigail Breslin, Seth Meyers, Steve Earle

John Krasinski, Joe Torre, José González

Conan O'Brien, Anderson Cooper, Allison Moorer

John Larroquette, Kid Inventors, k.d. lang

Jodie Foster, Cedric the Entertainer, Lili Haydn

Mike Huckabee; Emeril Lagasse; Chingy

Republican Presidential Candidate Mike Huckabee; Chef Emeril Lagasse; Chingy performs; JibJab Cartoon and Tonight Show Free For All.

Steve Carell, Kathie Lee Gifford, Ani DiFranco

Sen. Hillary Clinton, Patton Oswalt, Ferras

David Spade, Nora Hardwick, Ben Lee

Pamela Anderson; Mary J. Blige

Pamela Anderson; Mary J. Blige performs from the CD "Growing Pains."

Jules Sylvester; Maria Bartiromo; Finger Eleven

Jules Sylvester and reptiles; Maria Bartiromo; Finger Eleven performs from the CD "Them VS. You VS. Me."

Jimmy Kimme; Elon Gold; OneRepublic

From "jimmy kimme live!," Jimmy Kimme; Stand-up comedian, Elon Gold; the music of OneRepublic ("Dreaming Out Loud"); A Priest, A Rabbi, and a Minister Tell Jokes.

Keanu Reeves, Chelsea Handler, The Redwalls

William Shatner, Tricia Helfer, Ryan Bingham

Mark Harmon, Corbin Maxey, Ray J

Brad Garret; Ingrid Michaelson; John Melendez

Brad Garrett from "Til Death" and John Melendez from "One, Two, Many". The music of Ingrid Michaelson performing from the CD "Girls and Boys"

Charles Barkley, The Young@Heart Chorus

Ewan McGregor, John Cho & Kal Penn, Seether

Tracey Ullman, Jason Taylor, Flogging Molly

Dave Salmoni, Norm MacDonald, Ashlee Simpson

Julia Louis-Dreyfus, Jason Segel, Goldfrapp

Patrick Dempsey, Ed Begley Jr., Tegan and Sara

Gov. Arnold Schwarzenegger, Marilu Henner, Old 97's

Hugh Laurie, Doug Fine, Prince

Helen Hunt, Gov. Bobby Jindal, Duffy

Dr. Phil McGraw, the Lopez family, Natasha Bedingfield

Cindy McCain, Ed Helms, Augustana

Robin Williams, Terrence Howard, Serj Tankian

Sally Field, Jesse Ventura, Sleepercar

Robert Downey Jr., Carlos Mencia, Rascal Flatts

Julie Scardina and animals, Christina Ricci, KT Tunstall

Former President Jimmy Carter, Jon Favreau, P.O.D.

Jenna Fischer, Robert Schimmel, Trace Adkins

Harrison Ford, William Moseley, Carly Simon

Jack Black, Clay Aiken

Evangeline Lilly, Ben Barnes, Switchfoot

Rainn Wilson, Howard Dean, Kate Nash

Dana Delany, Adam Carolla, Dwight Yoakam

Matthew Fox, Kathleen Edwards

Simon Cowell, Rob Schneider, Josh Groban

Sylvester Stallone, Irma & Ray Ziff, Jason Mraz

Adam Sandler, Hilary Duff, Al Green

Laura & Jenna Bush, David Cook, Tristan Prettyman

Terry Bradshaw, Turkey Baster Virtuoso Ray Sanders, Colbie Caillat

William Shatner, Chelsea Handler, Newton Faulkner

Liv Tyler, Judd Apatow, Usher

Jeff Foxworthy, Arianna Huffington, N.E.R.D.

Dave salmoni; Patricia Arquette; Punch Brothers

Amazing animals with Dave salmoni! From "medium" Patricia Arquette! The music of Punch Brothers! " Jaywalking."

Will Smith, Pete Sampras, Ed Harcourt

Russel Brand, Bill Engvall, Aimee Mann

Justin Timberlake, Karen Allen, Sheryl Crow

Dana Carvey, Spencer Breslin, Priscilla Ahn

Mike Myers, Abigail Breslin, David Cook

Larry the Cable Guy, Bob Costas, Ashanti

Anne Hathaway; Gabriel Iglesias; Amos Lee

Anne Hathaway "Get Smart" - Comedian Gabriel Iglesias; Amos Lee: Performance from the CD "Last Days at the Lodge"; Headlines.

Ryan Phillippe; Lisa Lampanelli; Jim Lauderdale

Ryan Phillippe from "Stop-Loss", Lisa Lampanelli from "Drillbit Taylor" and music of Jim Lauderdale from the CD "Honey Songs".

Dwayne "The Rock" Johnson, Tom Papa, Against Me!

Wanda Sykes, James McAvoy, Duffy

Bette Midler, Al Roker

Selma Blair, Kevin Nealon, Steve Tyrell

Aaron Eckhart, Dara Torres, Los Lonely Boys

Animal Expert Jarod Miller, David Koechner, Sara Bareilles

Conan O'Brien; Anderson Cooper; Allison Moorer

Conan O'Brien; Anderson Cooper; Allison Moorer: Performance from the CD "Mockingbird"; and Mo Rocca on spring break in Florida.

John Larroquette; Kid Inventors; K.D. Lang

John Larroquette "Boston Legal"; Kid Inventors; K.D. Lang: Performance from the CD "Watershed"; "The 99 Cent Shopping Spree."

Jodie Foster; Cedric the Entertainer; Lili Hayden

Jodie Foster, Cedric the Entertainer, the music of Lili Hayden and "headlines."

David Beckham; Sherri Shepherd; B-52s

Soccer great, David Beckham, from "the view," Sherri Shepherd, the music of the B-52s. And "famous ad slogans and their first drafts."

Steve Carell; Kathie Lee Gifford; Ani LiFranco

Steve Carell; from the "Today" Show, Kathie Lee Gifford. The music of Ani LiFranco. And "Photo Booth."

Hillary Clinton; Patto Oswalt; Ferras

Senator Hillary Clinton, comedian Patto Oswalt; the Music of Ferras, and "jaywalking."

David Spade; Nora Hardwick; Ben Lee

David Spade "Rules of Engagement"; 102-year-old Nora Hardwick, Britain's oldest driver; Ben Lee performs from the CD " Ripe."

Thomas Haden Church; Sig & Edgar Hansen; Jimmy Eat World

Thomas Haden Church from "Smart People", Sig & Edgar Hansen from "The Deadliest Catch". The music of Jimmy Eat World from the CD "Chase This Light".

Dennis Quaid; Russell Brand; Brett Dennen

Dennis Quaid from "Smart People", Russell Brand from "Forgetting Sarah Marshall". The music of Brett Dennen performing "Ain't No Reason" from the CD "More So Much More".

Ellen Page; Donny & Marie Osmond; Angie Stone

Ellen Page from "Smart People", Donny & Marie Osmond from the "Miss USA Pageant". The music of Angie Stone performing from the CD "The Art of Love and War".

Keanu Reeves; Chelsea Handler; The Redwalls

Keanu Reeves from the movie "Street Kings", Chelsea Handler, the music of The Redwalls performing from the CD "The Redwalls".

William Shatner; Tricia Helfer; Ryan Bingham

William Shatner from "Boston Legal", Tricia Helfer from "Battlestar Galactica". The music of Ryan Bingham performing from the CD "Mescalito".

Mark Harmon; Corbin Maxey; Ray J

Mark Harmon from "NCIS" and 18-year-old reptile expert Corbin Maxey. The music of Ray J performing from the CD "All I Feel".

Brad Garrett; John Melendez; Ingrid Michaelson

Brad Garrett from "Til Death" and John Melendez from "One, Two, Many". The music of Ingrid Michaelson performing from the CD "Girls and Boys"

Charles Barkley; Young @ Heart Chorus

Charles Barkley and 3 Senior Rock Stars from "Young @ Heart Chorus". The music of Young @ Heart Chorus.

Rosie Perez, Robin Thicke

Bill Cosby, Emma Stone, John Mellencamp with T Bone Burnett

Ben Stiller, Jonas Brothers

Robert Downey Jr., Anna Faris, Toby Keith

Jack Black, Pillsbury Bake-Off-Champ Carolyn Gurtz, Conor Oberst

Nick Nolte, Carrot Top, Solomon Burke

Hugh Laurie; Doug Fine; Prince

Hugh Laurie "House"; Doug Fine "Environmental Author"; Prince: Performance from the CD "Planet Earth"; Jaywalking.

Sen. John McCain, Dara Torres, Juliana Hatfield

Norm MacDonald, Nastia Liukin, B.B. King

Bill Maher, Henry Cejudo, Low vs Diamond

Gordon Ramsay, Natalie Coughlin, Missy Higgins

Arsenio Hall, Shawn Johnson, Chuck Berry

Russell Brand, Eva Longoria Parker, Ingrid Michaelson

Billy Bob Thornton, Ethan Bortnick, Brian Wilson

Howie Mandel, Sanya Richards, The Game

Jenna Fischer; Robert Schimmel; Trace Adkins

Jenna Fischer "The Office"; Comedian Robert Schimmel; Trace Adkins: Performing "You're Gonna Miss This" from the CD "American Man".

Harrison Ford; William Moseley; Carly Simon

Harrison Ford "Indiana Jones"; William Moseley "The Chronicles of Narnia Prince Caspian"; Carly Simon: Performing "Hold Out Your Heart" from the CD "This Kind of Love"; The Audience Wants to Know.

Jules Sylvester, Annette Bening, Leona Lewis

Matthew McConaughey, T. Boone Pickens, Al Green

Jamie Lee Curtis, Jerome Bettis, Alejandro Escovedo

Hugh Laurie, Dame Edna, Raphael Saadiq

Matthew Fox; Kathleen Edwards

Matthew Fox "Speed Racer"; Kathleen Edwards: Performance from the CD "Asking for Flowers"

Simon Cowell; Rob Schneider; Josh Groban

Simon Cowell "American Idol"; Rob Schneider "You Don't Mess with the Zohan"; Josh Groban: Performance from the "Awake Live CD/DVD"; Headlines

Sylvester Stallone; Irma & Ray Ziff; Jason Mraz

Sylvester Stallone "Rambo"; Couple married 75 yrs. Irma & Ray Ziff; Jason Mraz: Performance from the CD "We Sing, We Dance, We Steal Things"; Does this Impress Ed Asner?

Adam Sandler; Hillary Duff; Al Green

Adam Sandler "You Don't Mess with the Zohan"; Hillary Duff "War, Inc."; Al Green: Performance from the CD "Lay It Down"; Summer Movie Knockoffs.

Laura & Jenna Bush; David Cook; Tristan Prettyman

Laura & Jenna Bush; American Idol winner David Cook; Tristan Prettyman: Performance from the CD "Hello"; Brian Herzlinger Talks to Third Graders who Want to become a President.

Terry Bradshaw; Ray Sanders; Colbie Caillat

Terry Bradshaw; Turkey baster virtuoso Ray Sanders; Colbie Caillat: Performance from the CD "Little Things;" Amaon.com's Worst Sellers.

Ellen Degeneres; Jerry O'Connell; Jazmine Sullivan